Adenovirus-induced Chromosome Aberrations in Human Cells

Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.

Previous studies on the clastogenic effects of mutagens on human sperm chromosomes were reviewed. A marked increase of structural chromosome aberrations (SCAs) has been reported in the spermatozoa irradiated in vitro with five kinds of ionizing radiation (137Cs gamma-, 60Co gamma-, X-, and 3H beta-rays and 252Cf neutrons). The micronucleus (MN) test with hybrid two-cell embryos generated from h...

Drinking beer reduces radiation-induced chromosome aberrations in human lymphocytes.

We here investigated and reported the effects of beer drinking on radiation-induced chromosome aberrations in blood lymphocytes. Human blood that was collected either before or after drinking a 700 ml beer was in vitro irradiated with 200 kVp X rays or 50 keV/microm carbon ions. The relation between the radiation dose and the aberration frequencies (fragments and dicentrics) was significantly (...

Potential of radiation-induced chromosome aberrations to predict radiosensitivity in human tumour cells.

PURPOSE To validate whether the number of aberrations could be used as a measure of the radiosensitivity of human tumour cells. If so, this would potentially provide a more rapid method than the colony assay to predict radiocurability in human tumour biopsy material. MATERIALS AND METHODS A panel of 13 human tumour cell lines was investigated, covering a wide range of radiosensitivities. Fluo...

Experimentally Induced Chromosome Aberrations in Plants

The discovery of Lilly and Thoday, that the presence of potassium cyanide (KCN) increases the production of chromosome aberrations by x-rays in anoxia, but has no effect on the production of chromosome aberrations by x-rays in air, was confirmed. In the presence of cyanide, the effect of a given dose of x-rays in nitrogen was found to be even greater than the effect of the same dose of x-rays i...

Persistent chromosome aberrations in irradiated human subjects.